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Substance Abuse Research

Research Topic

Of the more than 80 cannabinoid compounds produced by Cannabis Sativa L, the two major neuroactive components are delta-9-tetrahydrocannabinol (THC), which has euphoric effects, and cannabidiol (CBD), which is thought to lack euphoric effects.

Abuse Potential Assessment Of Cannabidiol (CBD) In Recreational Polydrug Users: A Randomized, Double-Blind, Controlled Trial

Drug addiction is a chronically relapsing disorder characterized by the compulsive desire to use drugs and a loss of control over consumption. Cannabidiol (CBD), the second most abundant component of cannabis, is thought to modulate various neuronal circuits in drug addiction.

Cannabidiol As An Intervention For Addictive Behaviors

Cannabidiol (CBD) is a non-psychoactive component of marijuana, which has anti-inflammatory effects. It has also been approved by FDA for various diseases for exploratory trials. Herein, we investigated the effects of CBD on liver injury induced by chronic plus binge alcohol feeding in mice.

Cannabidiol Attenuates Alcohol-Induced Liver Steatosis, Metabolic Dysregulation, Inflammation And Neutrophil-Mediated Injury

Recent evidence suggests that cannabidiol (CBD) may be useful for the treatment of different neuropsychiatric disorders. However, some controversy regarding its profile as a drug of abuse hampers the further development of basic and clinical studies.

Cannabidiol Does Not Display Drug Abuse Potential In Mice Behavior

The mechanism of action of cannabidiol, one of the major constituents of cannabis, is not well understood but a noncompetitive interaction with mu opioid receptors has been suggested on the basis of saturation binding experiments. The aim of this study was to examine whether cannabidiol is an allosteric modulator at this receptor, using kinetic binding studies.

Cannabidiol Is An Allosteric Modulator At Mu- And Delta-Opioid Receptors

Studies show that cannabidiol, the main non-psychotomimetic phytocannabinoid found in Cannabis sativa, reduces anxiety via 5-HT and (indirect) cannabinoid receptor activation in paradigms assessing innate responses to threat. Learning to associate cues or contexts with potential threats or rewards is adaptive and enhances survival. Both aversive and appetitive memories are therefore powerful drivers of behavior, but the inappropriate expression of conditioned responding to fear- and drug-related stimuli can develop into anxiety-related and substance abuse disorders respectively.

Cannabidiol Regulation Of Emotion And Emotional Memory Processing: Relevance For Treating Anxiety-Related And Substance Abuse Disorders

Cannabidiol (CBD), a non-toxicating cannabinoid found in cannabis, may be a promising novel smoking cessation treatment due to its anoxiolytic properties, minimal side effects and research showing that it may modify drug cue salience. We used an experimental medicine approach with dependent cigarette smokers to investigate if overnight nicotine abstinence, compared with satiety, will produce greater attentional bias.

Cannabidiol Reverses Attentional Bias To Cigarette Cues In A Human Experimental Model Of Tobacco Withdrawal

Currently, there is no approved pharmacotherapies for addiction to cocaine and other psychostimulant drugs. Several studies have proposed that cannabidiol (CBD) could be a promising treatment for substance use disorders. In the present work, the authors describe the scarce preclinical and human research about the actions of CBD on the effects of stimulant drugs.

Cannabidiol Treatment Might Promote Resilience To Cocaine And Methamphetamine Use Disorders: A Review Of Possible Mechanisms

Epidemics require a paradigm shift in thinking about all possible solutions. The rapidly changing socio-political marijuana landscape provides a foundation for the therapeutic development of medicinal cannabidiol to address the current opioid abuse crisis.

Cannabidiol: Swinging The Marijuana Pendulum From ‘Weed’ To Medication To Treat The Opioid Epidemic

Substance use disorder is characterized by repeated use of a substance, leading to clinically significant distress, making it a serious public health concern. The endocannabinoid system plays an important role in common neurobiological processes underlying substance use disorder, in particular by mediating the rewarding and motivational effects of substances and substance-related cues.

Cannabidiol’s Promise For The Treatment Of Substance Use Disorder

Whereas Tetracannabinol hs been well documented to be rewarding and to enhance sensitivity to other drugs, cannabidiol (CBD), in contrast, appears to have low reinforcing properties with limited abuse potential and to inhibit drug-seeking behavior.

Early Phase In The Development Of Cannabidiol As A Treatment For Addiction: Opioid Relapse Takes Initial Center Stage

Cannabis use is common in people on opioid agonist treatment (OAT), causing concern for some care providers. However, there is limited and conflicting evidence on the impact of cannabis use on OAT outcomes. Given the critical role of retention in OAT in reducing opioid-related morbidity and mortality, we aimed to estimate the association of at least daily cannabis use on the likelihood of retention in treatment among people initiating OAT.

High-Intensity Cannabis Use Is Associated With Retention In Opioid Agonist Treatment: A Longitudinal Analysis

Cannabidiol (CBD) is a naturally occurring constituent of the marijuana plant. In the past few years, there has been great interest in the therapeutic effects of isolated CBD and it is currently being explored for numerous disease conditions (e.g. pain, epilepsy, cancer, various drug dependencies). However, CBD remains a Schedule I drug on the U.S. Controlled Substance Act (CSA). Despite its status, there are no well-controlled data available regarding its abuse liability.

Oral Cannabidiol Does Not Produce A Signal For Abuse Liability In Frequent Marijuana Smokers

The endogenous cannabinoid (eCB) system plays an important role in the pathophysiology of both psychotic disorders and substance use disorders (SUDs). The non-psychoactive cannabinoid compound, cannabidiol (CBD) is a highly promising tool in the treatment of both disorders.

The Potential Of Cannabidiol As A Treatment For Psychosis And Addiction: Who Benefits Most? A Systematic Review

The revolution on cannabinoid research started when the primary psychoactive constituents of cannabis (delta)8-THC and (delta)9-THC, were isolated in 1964. This finding triggered the identification and cloning of its cellular target, the cannabinoid receptor (CB1), and a second mainly peripheral CB2 receptor.

The Role Of The Endocannabinoid System In Addictive Behavior

Cannabidiol (CBD), the major non-psychoactive constituent of Cannabis Sativa, has received attention for therapeutic potential in treating neurologic and psychiatric disorders. Recently, CBD has also been explored for potential in treating drug addiction. Substance use disorders are chronically relapsing conditions, and relapse risk persists for multiple reasons including craving induced by drug contexts, susceptibility to stress, elevated anxiety, and impaired impulse control.

Unique Treatment Potential Of Cannabidiol For The Prevention Of Relapse To Drug Use: Preclinical Proof Of Principle

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