A Phase I Randomized Double-Blind Placebo-Controlled Single Ascending Dose Multiple Dose Food Effect Trial Of Safety, Tolerability And Pharmacokinetics Of Highly Purified Cannabidiol In Healthy Subjects

A formal single ascending and multiple dose pharmacokinetic (PK) trial of cannabidiol (CBD) oral solution was required to determine the safety and tolerability of CBD, the maximum tolerated dose, and to examine the effect of food on CBD PK parameters.

Biological Bases For A Possible Effect Of Cannabidiol In Parkinson’s Disease

Current pharmacotherapy of Parkinson’s disease (PD) is palliative and unable to modify the progression of neurodegeneration. Treatments that can improve patients’ quality of life with fewer side effects are needed, but not yet available. Cannabidiol (CBD), the major non-psychotomimetic constituents of cannabis, has received considerable research attention in the last decade.

Cannabidiol As A Potential Treatment For Anxiety And Mood Disorders: Molecular Targets And Epigenetic Insights From Preclinical Research

Since CBD interacts with a wide variety of molecular targets in the brain, its therapeutic potential has been investigated in a number of neuropsychiatric diseases, including anxiety and mood disorders. Specifically, CBD has received growing attention due to its anxiolytic and antidepressant properties.

Cannabidiol As A Potential Treatment For Psychosis

Psychotic disorders such as schizophrenia are heterogeneous and often debilitating conditions that contribute substantially to the global burden of disease. The introduction of dopamine D2 receptor antagonists in the 1950’s revolutionised the treatment of psychotic disorders and they remain the mainstay of our treatment arsenal for psychosis. However, traditional antipsychotics are associated with a number of side effects and a significant portion of patients do not achieve an adequate remission of symptoms.

Effectiveness Of Cannabidiol Oil For Pediatric Anxiety And Insomnia As Part Of Posttraumatic Stress Disorder: A Case Report

Anxiety and sleep disorders are often the result of posttraumatic stress disorder and can contribute to an impaired ability to focus and to demonstration of oppositional behaviors. Cannabidiol oil, an increasingly popular treatment for anxiety and sleep issues, has been documented as being an effective alternative to pharmaceutical medications. This case study provides clinical data that support the use of cannabidiol as a safe treatment for reducing anxiety and improving sleep in a young girl with posttraumatic stress disorder.

Effects Of CBD-Enriched Cannabis Sativa Extract On Autism Spectrum Disorder Symptoms: An Observational Study Of 18 Participants Undergoing Compassionate Use

Autism Spectrum Disorder comprise conditions that may affect cognitive development, motor skills, social interaction, communication, and behavior. This set of functional deficits often results in lack of independence for the diagnosed individuals, and severe distress for patients, families, and caregivers.

Effects Of Cannabidiol On Brain Excitation And Inhibition Systems; A Randomized Placebo-Controlled Single Dose Trial During Magnetic Resonance Spectroscopy In Adults With And Without Autism Spectrum

There is increasing interest in the use of cannabis and its major non-intoxicating component cannabidiol (CBD) as a treatment for mental health and neurodevelopmental disorders, such as autism spectrum disorder (ASD). However, before launching large-scale clinical trials, a better understanding of the effects of CBD on brain would be desirable.

Efficacy And Safety Of Cannabidiol Plus Standard Care Vs Standard Care Alone For The Treatment Of Emotional Exhaustion And Burnout Among Frontline Health CareWorkers During The COVID-19 Pandemic

Frontline health care professionals who work with patients with COVID-19 have an increased incidence of burnout symptoms. Cannabidiol (CBD) has anxiolytic and antidepressant properties and may be capable of reducing emotional exhaustion and burnout symptoms.

From Cannabis Sativa To Cannabidiol: Promising Therapeutic Candidate For The Treatment Of Neurodegenerative Diseases

Cannabis sativa, commonly known as marijuana, contains a pool of secondary plant metabolites with therapeutic effects. Besides D9-tetrahydrocannabinol that is the principal psychoactive constituent of Cannabis, cannabidiol (CBD) is the most abundant nonpsychoactive phytocannabinoid and may represent a prototype for anti-inflammatory drug development for human pathologies where both the inflammation and oxidative stress (OS) play an important role to their etiology and progression.

Glial Cells And Their Contribution To The Mechanisms Of Action Of Cannabidiol In Neuropsychiatric Disorders

During the first decades of neuroscience and psychopharmacology research, glial cells and cannabidiol (CBD) did not play a major role in modifying brain functions. Currently, however, both CBD and glial cells, initially thought as secondary components, are recognized as major players in the central nervous system (CNS) physiology and Cannabis sativa pharmacology, respectively.

Neuroprotective And Neuromodulatory Effects Induced By Cannabidiol And Cannabigerol In Rat Hypo-E22 Cells And Isolated Hypothalamus

Cannabidiol (CBD) and cannabigerol (CBG) are non-psychotropic terpenophenols isolated from Cannabis sativa, which, besides their anti-inflammatory/antioxidant effects, are able to inhibit, the first, and to stimulate, the second, the appetite although there are no studies elucidating their role in the hypothalamic appetite-regulating network. Consequently, the aim of the present research is to investigate the role of CBD and CBG in regulating hypothalamic neuromodulators.

Pathways And Gene Networks Mediating The Regulatory Effects Of Cannabidiol, A Nonpsychoactive Cannabinoid, In Autoimmune T Cells

Our previous studies showed that the non-psychoactive cannabinoid, cannabidiol (CBD), ameliorates the clinical symptoms in mouse myelin aligadenrocyte glyoprotein (MOG) 35-55-induced experimental autoimmune encephalomyelitis model of multiple sclerosis (MS) as well as decreases the memory MOG35-55-specific T cells (Tmcg) proliferation and cytokine secretion including IL-17, a key autoimmune factor. The mechanisms of these activities are currently poorly understood.

Plastic And Neuroprotective Mechanisms Involved In The Therapeutic Effects Of Cannabidiol In Psychiatric Disorders

Beneficial effects of cannabidiol (CBD) have been described for a wide range of psychiatric disorders, including anxiety, psychosis, and depression. The mechanisms responsible for these effects, however, are still poorly understood. Similar to clinical antidepressants or atypical anti-psychotic drugs, recent findings clearly indicate that CBD, either acutely or repeatedly administered, induces plastic changes.

Progress In Neuropsychopharmacology And Biological Psychiatry

Autism Spectrum Disorder (ASD) is characterized by persistent deficits in social communication, restricted and repetitive patterns of behavior, interests, or activities and often intellectual disabilities. ASD has a number of prevalent co-morbidities, such as sleep disorders, attention deficit/hyperactivity disorder and epilepsy.

Prolonged Cannabidiol Treatment Lacks On Detrimental Effects On Memory, Motor Performance And Anxiety

The Cannabis plant contains more than 100 currently known phytocannabinoids. Regarding the rising consumption of the non-psychotropic phytocannabinoid cannabidiol (CBD) in people’s everyday life (e.g. beauty products, food and beverages), the importance of studies on the influence of CBD on healthy humans and rodents is evident.

The Effect Of Cannabidiol On Low-Frequency Activity And Functional Connectivity In The Brain Of Adults With And Without Autism Spectrum Disorder

The potential benefits of cannabis and its major non-intoxicating component cannabidiol (CBD) are attracting attention, including a potential treatment in neurodevelopment disorders such as autism spectrum disorder (ASD). However, the neural action of CBD, and its relevance to ASD, remains unclear. We and others have previously shown that response to drug challenge can be measured using functional magnetic resonance imaging (MRI), but that pharmacological responsivity is atypical in ASD.

Therapeutic Effects Of Cannabinoids In Animal Models Of Seizures, Epilepsy, Epileptogenesis, And Epilepsy-Related Neuroprotection

The isolation and identification of the discrete plant cannabinoids in marijuana revived interest in analyzing historical therapeutic claims made for cannabis in clinical case studies and anecdotes. In particular, sources as old as the 11th and 15th centuries claimed efficacy for crude marijuana extracts in the treatment of convulsive disorders, prompting a particularly active area of preclinical research into the therapeutic potential of plant cannabinoids in epilepsy.

Translating Endocannabinoid Biology Into Clinical Practice – Cannabidiol For Stroke Prevention

The endocannabinoid system (ECS) regulates functions throughout human physiology, including neuropsychiatric, cardiovascular, autonomic, metabolic, and inflammatory states. The complex cellular interactions regulated by the ECS suggest a potential for vascular disease and stroke prevention by augmenting central nervous and immune cell endocannabinoid signaling.

Translational Investigation Of The Therapeutic Potential Of Cannabidiol

Among the many cannabinoids in the cannabis plant, cannabidiol (CBD) is a compound that does not produce the typical effects of marijuana. The aim of the present review is to describe the main advances in the development of the experimental and clinical use of cannabidiol CBD in neuropsychiatry.

Treatment Of Fragile X Syndrome With Cannabidiol

Fragile X Syndrome (FXS) is an X-linked dominant disorder caused by a mutation in the fragile X mental retardation 1 gene. Cannabidiol (CBD) is an exogenous phytocannabinoid with therapeutic potential for individuals with anxiety, poor sleep, and cognitive deficits, as well as populations with endocannabinoid deficiencies, such as those who suffer from FXS.

Neurological